Betsy Cain was born in Tuscaloosa, Alabama and grew up in Fairfield, Alabama, the steel mill city near Birmingham. She received both her BFA and MFA from The University of Alabama, but did formative undergraduate work at Auburn University and Instituto Allende, San Miguel de Allende, Mexico. Cain has been based in Savannah, Georgia, for over thirty years.
Cain's work is heavily rooted in abstraction, and her intimate relationship with the natural environments of the south.
Most recently, she exhibited in New York City at the National Arts Club alongside fellow artists, Marcus Kenney and Cedric Smith. The show aims to comment on representation of place, specifically the American South.